5 Best Drain Cleaners - July 2022 - BestReviews Alkaline drain cleaners, on the other hand, typically use lye as the main ingredient. The main benefit is that they're not as corrosive as acidic drain openers. While they may not be quite as strong, they still do a very good job dissolving obstacles and clearing drains. Expert Tip Always wear gloves when attempting to unclog your drains.